The ITGAV Polyclonal Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to CD51, Integrin Alpha V, Integrin alphaV, Integrin alphaVbeta3, and ITGAV. This antibody recognizes Human, Mouse, and Rat antigen. The ITGAV Polyclonal Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
Integrins are alpha/beta heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 alpha and 8 beta subunits that form 24 known integrins with distinct tissue distribution and overlaping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with extracellular environment (inside-out signaling) (1,2).Several alphaV subfamily members, including alphaVbeta3, alphaVbeta5, alphaVbeta1, are highly expressed in active endothelial cells and cancer cells (3-6) where they play a critical role in angiogenesis and tumor metastasis (7-9). Therefore, interest has focused on alphaV integrin as a key therapeutic target in the treatment of cancer (10-12)